MUC2;

Mucin-2;

s

Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.

s

MGLRAASLFMLWLALSNTSEIRKGRTRNHGHYVCSTWGNNHFKTFDGDIYQFPGMCEYNFVSDCQDSYREFSVHIQRALNSNNHPEIQYILITVTDFTVYLKPKLAVVDGRIVKTPYYSSGLLIESNDIYTKVYAKLGLILIWNQEDALMVELDSKFGNQTCGLCGDYNGVPIYNEFISGVASYNSITYGNLQKISKPNDECEDPDETRALPSCNEHREECEKLLTSSAFADCHSRLNLEMYIQACMQDKCACKGNEDSFCLCSTISEYSRQCSHAGGRPGEWRTENFCYKTCPGNMVYRESSSPCMDTCSHLEVSSLCEEHYMDGCFCPEGTVYDDITENGCIPVSQCSCRLHGKGYSPGETITNECEECTCDSGRWTCKDLPCPGTCSVEGGSHIKTFDGKKYTFHGDCYYVLAKSAVNDTHALLAELAPCGSSDGQTCLKTVVLLVDDKKNVVVFRSDGSVSLNEMTVNVPHVSASFSVFKPSSYYLIVHTSFGLQLQIQLSPVMQLFVTADQSVQDIQGLCGNFNGMEGDDFKTTNGLVEATGSAFANTWKAQPTCADQAEKLEDPCTLSIESANYAEHWCSLLKNSEGPFARCHSVIDPAEYYKRCKYDTCLCKDNEECLCAALSSYSRACAFKGIILGGWRQSVCSDEVSACPGNQVFLYNLTMCQQTCRSIADGEKYCLQDFAPVDGCGCPDNTYLDNQDTCVPISKCPCYYKGSYLEPGEYVTKDGERCVCRNAKIRCTSVTMRMKSITECPSNKTYFDCNASPDWTSRTPVQLRCGTSQTDLYQGECVSGCVCPEGLFDDGRGGCVEEEDCPCIHNSDWYNHGQSITVDCNTCTCQKGIWSCTKNVCYGTCMIYGSGHYITFDGKFYDFDGSCEYVATQDYCGDKNSGGSFSIITENVPCGTTGVTCSKAIKMFIGKTELKLENKDYKEIQRDVGDDVHYQNKTVGLYLVIEASNGVMLIWDKKTTVFIKLTPDYKGKVCGLCGNFDDKANNDFTSRNGLQETNALTFGNSWKQSSVCPDVTEEIKPCDLKPHRKSWAEKECSLILSEIFKICHSKVNPSPFYDACVHDACSCDSGGDCDCFCSAVAAYAQECTKAQACVFWRSPDICPIFCDYYNPRNECEWHYEPCGSNVMTCRMLYNVSTNFSVPYLEGCYPRCPHEKPVYNEETKECVAADECWCYHNGKPVIIGGEIPTEENCTKCICRPSGSIECTPIPGCPCVINGTSYEVGQTVATIKDGDICTTYVCAENGSVVPGSTYPCPLTTSPSTITTSPGTSTLTTIVTTSPPVPTTPCLVLICDWSEWFDVSNPEEDGGDYETYDAIRIEHGNKICAAPENIECRAKDSPDKTLEELGQKVECNVTYGLICKNEEQDASIWHLCYNYEIRVNCCEWHEIPCDAGPSSTPTASSVTTGTTVPTTTTQQSTTITTIPTPTATTTSQSPPSVTSGSTVSTTAPTPTPSESPTSTTTTTPFSSSSQGATPTVPGVSSSIPTVTSTVLPPIVTQTHSPPPSQPVGNCECTWTDWIDSSQPDRSDVNSGDYETIDKINNSSFVCVKAENISCRAKDYPNISLEELGQKVECSVNTGLICNNKDQENNGHVSYCHNYEINVCCTPNKPECIPSTELVTTISTPVSHSTTTTIVFTSTVSSTAATTTPTGSAPTTTSGTMPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPRPTPTTSVTRPPTSTEGPTPESTTRTTVSSSSAPPTPTGSSPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVTTSTPGPTPTSSVTPPPTATEIVCTFPPEDCIWTDWIDVSYPQFGPEGGDDETFETIQNKIPSWNCTKVENVSCRAEKFPDIPIEDLGQKVECDVNTGLICKNKDQTTGGVIPMPVCLNYQIKVCCAPPLSPECTTAVTTTTTGETSTTVSLSPTTSTRYTPSVSSTTSPPTPTGSAPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTTSVTRPPTSTEGPTPESTTRTTVSSSSAPPTPTGSSPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTTSVTRPPTSTEGPTSQSTTSTTVSSPSVSSSSAPPTPTGSSPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTTSVTRPPTSTEGPTPESTTRTTVSSSSAPPTPTGSSPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTTSVTRPPTSTEGPTSQSTTSTTVSSPSVSSSSAPPTPTGSSPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTTSVTRPPTSTEGPTPESTTRTTVSSSSAPPTPTGSSPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTSSVTPPPTATEIVCTFPPEDCIWTDWIDVSYPWFGPEGGDDETFETIQNKIPSWNCTKVENVSCRAEKFPDIPIEDLGQKVECDVNTGLICKNKDQTTGGVIPMPVCLNYQIKVCCAPPLSPECTTAVTTTTTGETSTTVSLSPTTSTRYTPSVSSTTSPPTPTGSAPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTTSVTRPPTSTEGPTPESTTRTTVSSSSAPPTPTGSSPTTTSGTTPSSSTIGSTVSTTPVTSPPSPSPTSVSTSTPGPTPTTSVTRPPTSTEGNCLAVVPRVPLLRENLTSSYSTTILTGSFSTEGTTTVSESSSTASVSTPVNTQSTGASSPLLTPSGSMSPPSVSTVPSTVTTSGTTPTKPFTTTSGTTSSSFSTVTATTITTSEIVSSGSASTSGTTPASSTVTVSGSSTYSTLTTLSTLSSTASSSSNCTISPNETHAPGESWWLCNCTKAICVENNTVVIVPVICEPPPKPTCSNGLAPVQVIDDDLCCWHWECDCYCTGWGDPHYMTFDGLYYSYQGNCTYVLVEEIEKRVDNFGVYIDNYHCDARDIVSCPRALIVRHETQEVRIVTVKPNTLEVEVTVNKQPVALPYKKFGLSVYESGINRVVEIPELKMNVSFNGLSFSIRMPYSLFGNNTQGQCGICNNNTADDCRLPNGNIAENCETMADYWQVVDPSKPQCSPGLVPTKAPSTTTGQPCKESSLCELLWGSVFEKCREVVKPDKYYAACVFDSCTLPDLDLECSSLQIYAAICADQNVCVDWRSHTNGVCCSYECPKHKEYRACGPIQETTCKSSPQNETSIKQIEGCFCPNGTMLFDSGVDVCVNTCGCVGLDMIPREFGEKFTADCQDCVCLEGGNGIVCEHHKCPEQNKKSCSGKGFYEVTVVNSEDPCCPTVTCKCNTSLCTTEPPKCTLGFEVFSYIPSDECCPVYKCVPKKVCVHQNAEFLPNSSVFVDKCHNCFCTNEVNISTQLNVISCERIPCNTYCEPGYELQHVQGECCGKCVQTKCVIHTSHSSNLILNPGEFINDPYNNCTIYSCTSIKNQLISSTSEITCPAFNEESCKPGTVTFLPNGCCKTCIPLDSPTPCSVRERKDFIVYKNCRSLERVVLTECEGTCGTFSLYSVEASSMEHSCSCCKEVETSMKEVELKCPSGHSITHKYVYVESCGCQDTQCIVPESSESQSTEENDESTQNHKRRAISLTSK

N/A

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